Immune lysis of normal human and paroxysmal nocturnal hemoglobinuria (PNH) red blood cells. I. The sensitivity of PNH red cells to lysis by complement and specific antibody.
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چکیده
منابع مشابه
Immune Lysis of Normal Human and Paroxysmal Nocturnal Hemoglobinuria (pnh) Red Blood Cells
1. The defects produced on the membrane of the human red blood cell by the action of complement and antibody have been studied by the use of the electron microscope. These are round to slightly ovoid holes and are surrounded by an irregular ring, about 20 A thick. The mean diameter of the holes is about 103 A if human complement is used (regardless of the antibody used for sensitization) and ab...
متن کاملMechanisms of immune lysis of the red cells in hereditary erythroblastic multinuclearity with a positive acidified serum test and paroxysmal nocturnal hemoglobinuria.
The red cells of patients with hereditary erythroblastic multinuclearity with a positive acidified serum test (HEMPAS), a form of congenital dyserythropoietic anemia, and the cells of patients with paroxysmal nocturnal hemoglobinuria (PNH) are lysed more readily than normal cells by certain antibodies, notably cold agglutinins (anti-I) and complement. With some but not other examples of anti-I,...
متن کاملInhibitors of complement derived from the erythrocyte membrane in paroxysmal nocturnal hemoglobinuria.
Extracts of the membranes of normal red cells and red cells from all subpopulations of paroxysmal nocturnal (PNH) red cells inhibited antibody-mediated complement activation. These extracts were shown to accelerate decay of the complement complex. C42, and the relative amount of inhibitory activity was similar in normal and PNH membranes. Inhibitors derived from normal red cells markedly decrea...
متن کاملLeukocyte antigen-antibody reaction and lysis of paroxysmal nocturnal hemoglobinuria erythrocytes.
T HE TRANSFUSION OF COMPATIBLE WHOLE BLOOD to patients suffering from paroxysmal nocturnal hemoglobinuria ( PNH ) is known to sometimes cause a hemolytic reaction. It has been suggested that leukocyte isoantibodies present in the patient’s serum through interaction with the donor’s leukocyte antigens are responsible for lysis of PNH red cells.’ As yet, it has not been clarified why this interac...
متن کاملDifferences in the terminal steps of complement lysis of normal and paroxysmal nocturnal hemoglobinuria red cells.
The number of microscopically visible lesions produced on the membrane for a given degree of lysis on normal cells as on PNH cells. Since complement lesions were not formed until C8 or C9 was incorporated into the complement sequence, the results suggest that increased lysis of red cells in PNH is due at least in part to more efficient penetration of the PNH membrane by the terminal lytic seque...
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ورودعنوان ژورنال:
- The Journal of clinical investigation
دوره 45 5 شماره
صفحات -
تاریخ انتشار 1966